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The 4/4 was really viewed as, "Boy, you're guaranteed to have an MI before 60." And I think the evidence today suggests that once you normalize and correct for LDL particle number or ApoB, it stops mattering

A study from the University of Pennsylvania and Cedars-Sinai Medical Center found a 700% increase in use of the drugs for patients without diabetes from 2019 to 2023

Depression, anxiety and perceived stress in women with and without PCOS: a community-based study

Effect of various PDE inhibitors on smooth muscle tone and cyclic nucleotide levels in vitro

(A weight-related condition is a health problem linked to excess weight, such as high blood pressure, high cholesterol, type 2 diabetes, prediabetes, fatty liver disease, or sleep apnea.) Semaglutide (Ozempic, Wegovy, Rybelsus) Ozempic and Rybelsus are approved for type 2 diabetes